Acupuncture for Fertility NY

Fertility Acupuncture Research – New York, NYC

  1. Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy.
  2. Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis.
  3. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial.
  4. Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection.
  5. Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization–embryo transfer treatment.
  6. Low-frequency electro-acupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome (PCOS).

Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy.

Objective: To evaluate the effect of acupuncture on the pregnancy rate in assisted reproduction therapy (ART) by comparing a group of patients receiving acupuncture treatment shortly before and after embryo transfer with a control group receiving no acupuncture.

Result(s): Clinical pregnancies were documented in 34 of 80 patients (42.5%) in the acupuncture group, whereas pregnancy rate was only 26.3% (21 out of 80 patients) in the control group.

Conclusion(s): Acupuncture seems to be a useful tool for improving pregnancy rate after ART.

Paulus Wolfgang, Mingmin Zhang, Erwin Strehler, Imam El-Danasouri, and Karl Sterzik. Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy., Fertility and Sterility, Volume 77, No. 4, April, 2002, pp 721-724.

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Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis.

Objective: To evaluate whether acupuncture improves rates of pregnancy and live birth when used as an adjuvant treatment to embryo transfer in women undergoing in vitro fertilization.

Data synthesis: Seven trials with 1366 women undergoing in vitro fertilization were included in the meta-analyses. There was little clinical heterogeneity. Trials with sham acupuncture and no adjuvant treatment as controls were pooled for the primary analysis. Complementing the embryo transfer process with acupuncture was associated with significant and clinically relevant improvements in clinical pregnancy (odds ratio 1.65, 95% confidence interval 1.27 to 2.14; number needed to treat (NNT) 10 (7 to 17); seven trials), ongoing pregnancy (1.87, 1.40 to 2.49; NNT 9 (6 to 15); five trials), and live birth (1.91, 1.39 to 2.64; NNT 9 (6 to 17); four trials). Since data was unable to obtained on live births for three of the included trials, the pooled odds ratio for clinical pregnancy more accurately represents the true combined effect from these trials rather than the odds ratio for live birth. The results were robust to sensitivity analyses on study validity variables. A pre-specified subgroup analysis restricted to the three trials with the higher rates of clinical pregnancy in the control group, however, suggested a smaller non-significant benefit of acupuncture (odds ratio 1.24, 0.86 to 1.77).

Conclusion: Current preliminary evidence suggests that acupuncture given with embryo transfer improves rates of pregnancy and live birth among women undergoing in vitro fertilization.

Manheimer E, Zhang G, Udoff L, et al. Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilization: systematic review and meta-analysis., British Medical Journal, 2008; 336(7643): pp. 545-549.

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Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial.

Objective: To evaluate the effect of acupuncture on reproductive outcome in patients treated with IVF/intracytoplasmic sperm injection (ICSI). One group of patients received acupuncture on the day of ET, another group on ET day and again 2 days later (i.e., closer to implantation day), and both groups were compared with a control group that did not receive acupuncture.

Result(s): Clinical and ongoing pregnancy rates were significantly higher in the ACU 1 group as compared with controls (37 of 95 [39%] vs. 21 of 87 [26%] and 34 of 95 [36%] vs. 19 of 87 [22%]). The clinical and ongoing pregnancy rates in the ACU 2 group (36% and 26%) were higher than in controls, but the difference did not reach statistical difference.

Conclusion(s): Acupuncture on the day of ET significantly improves the reproductive outcome of IVF/ICSI, compared with no acupuncture. Repeating acupuncture on ET day +2 provided no additional beneficial effect.

Lars G. Westergaard, Qunhui Mao, Marianne Krogslunda, Steen Sandrinic, Suzan Lenz, Jorgen Grinsted. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial., Fertility and Sterility, Volume 85, No. 5, May, 2006, pp 1341-1346.

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Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection.

Objective: To determine the effect of luteal-phase acupuncture on the outcome of IVF/intracytoplasmic sperm injection (ICSI).

Result(s): In group I, the clinical pregnancy rate and ongoing pregnancy rate (33.6% and 28.4%, respectively) were significantly higher than in group II (15.6% and 13.8%).

Conclusions(s): Luteal-phase acupuncture has a positive effect on the outcome of IVF/ICSI.

Dieterle S, Ying G, Hatzmann W, Neuer A. Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection., Fertility and Sterility, Volume 85, No. 5, May, 2006, pp 1347-1351.

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Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization–embryo transfer treatment.

Objective: To determine whether changes in serum cortisol (CORT) and prolactin (PRL) are affected by acupuncture (Ac) in Ac-treated IVF patients.

Result(s): CORT levels in AC group were significantly higher on IVF medication days 7, 8, 9, 11, 12, and 13 compared with controls. PRL levels in the AC group were significantly higher on IVF medication days 5, 6, 7, and 8 compared with controls.

Conclusion(s): In this study, there appears to be a beneficial regulation of cortisol and prolactin in the acupuncture group during the medication phase of the IVF treatment with a trend toward more normal fertile cycle dynamics.

P.C. Magarelli, D.K. Cridennda and M. Cohen. Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization–embryo transfer treatment., Fertility and Sterility, In Press, Corrected Proof, December, 2008.

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Low-frequency electro-acupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome.

Objective: The aim of the present study was to investigate the effect of these interventions on sympathetic nerve activity in women with Poly Cystic Ovarian Syndrome (PCOS).

Design: Randomized controlled trial.

Result(s):

  • Both the acupuncture and exercise groups significantly decreased muscle sympathetic nerve activity compared to the control group.  (Low-frequency electro-acupuncture (EA) was statistically significant at (P = 0.036) and physical exercise  was statistically significant at (P = 0.030).
  • The acupuncture group experienced a drop in waist size (P = 0.001), but not a drop in body mass index or weight.
  • The exercise group experienced a drop in weight (P = 0.004) and body mass index but not in waist size.
  • The acupuncture group experienced fewer menstrual irregularities but the exercise group’s irregularities did not change.
  • In the acupuncture group, there was a significant drop in testosterone. This is an important indicator because the strongest independent predictor of high sympathetic nerve activity in women is the level of testosterone.

Conclusion(s): “This is the first study to demonstrate that repeated low-frequency electro-acupuncture and physical exercise can reduce high sympathetic nerve activity seen in women with PCOS,” according to the authors. “Furthermore, both therapies decreased measures of obesity while only low-frequency electro-acupuncture improved menstrual bleeding pattern.”

Stener-Victorin et al. Low-frequency electro-acupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome., American Journal of Physiology & Regulatory Integrative and Comparitve Physiology, June 3, 2009.

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